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KMID : 0380420030270010031
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Journal of Prventive Veterinary Medicine
2003 Volume.27 No. 1 p.31 ~ p.40
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A Genetic Comparison of Vancomycin Resistant Enterococci Isolated from Animals and Human by Random Amplified Polymorphic DNA Typing
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조윤상/Cho, Yun-Sang
이희수/김종만/류판동/박용호/유한상/이문한/Lee, Hee-Soo/Kim, Jong-Man/Ryu, Pan-Dong/Park, Yong-Ho/Yoo, Han-Sang/Lee, Mun-Han
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Abstract
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It has been recently reported the possibility in the transfer of antimicrobial resistant to other animals and humans. In particular, the occurrence of vancomycin resistant enterococci (VRE), which have been known as a principal antimicrobial resistant bacteria in humans, has been increased as a pathogen of nosocomial infections. And then animal VRE were suspected as an origin of human VRE. In this work, we investigated the relatedness between VRE from animals and humans through random amplified polymorphic DNA (RAPD) typing. The genetic relatedness of vanA, vanB, vanC-1 and vanC-2 genotypes was examined by RAPD typing, respectively. van4 genotypes have not been shown high genetic relationship each other, containing VRE from humans (n = 8) and chickens (n = 5). In vanB genotypes from humans (n = 3), 2 isolates were made up one cluster, shown 77.8% homology. Chicken isolates of vanC-1 genotypes (n = 11) were constituted 2 clusters and the homology of 2 clusters was 81.8% and 80.0%, respectively. In case of vanC-2 genotypes (n = 19), 2 isolates from pigs have been shown 76.9% homology. But, between VRE from animals and humans, the isolates of high genetic relationship could not be found and RAPD typing was a useful epidemiological method that could be confirmed the genetic relationship among VRE.
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